
FDA’s chief vaccine official Dr. Peter Marks resigns after reportedly being forced out amid escalating tensions with HHS Secretary Robert F. Kennedy Jr. over vaccine safety and misinformation concerns.
Key Takeaways
- Dr. Peter Marks, FDA’s top vaccine official since 2016, was reportedly given the choice to resign or be fired and will leave his position effective April 5.
- Marks directly accused HHS Secretary Robert F. Kennedy Jr. of prioritizing “misinformation and lies” over “truth and transparency” in his resignation letter.
- The resignation occurs amid a measles outbreak that Marks linked to undermined public confidence in established vaccine science.
- Marks played a critical role in COVID-19 vaccine development and approval through “Operation Warp Speed.”
- Kennedy, who has a history of vaccine skepticism, had promised during confirmation hearings not to undermine vaccine confidence.
Forced Resignation Amid Policy Conflicts
Dr. Peter Marks, who has led the FDA’s vaccine division since 2016, has submitted his resignation effective April 5 following what sources describe as an ultimatum from Health and Human Services. According to multiple reports, Marks was given the choice to resign or be fired by an HHS official. The departure marks a significant shift in leadership for the vaccine regulation branch of the FDA, which Marks has steered through the COVID-19 pandemic and the development of multiple vaccines under Operation Warp Speed.
In his resignation letter to Acting FDA Commissioner Sara Brenner, Marks did not mince words about his reasons for leaving. He directly criticized Secretary Kennedy’s approach to vaccine science and public health communication, suggesting a fundamental disconnect between his approach and the secretary’s priorities.
ARREST Bill Gates.
“None of the vaccines that are given during the first 6 months of life have ever been tested for Autism…the only one tested was the DTP…and a study found that there was a link…which the CDC threw out…” -HHS RFK Jr. pic.twitter.com/xoZJZi98Qy
— Liz Churchill (@liz_churchill10) March 28, 2025
Clash Over Vaccine Science and Public Messaging
The conflict between Marks and Kennedy appears to center on differing approaches to vaccine safety and public messaging. Kennedy, who has long been associated with vaccine skepticism, claims to be “pro-safety” rather than “anti-vaccine.” However, Marks has been outspoken about the dangers of undermining public confidence in vaccines, pointing specifically to the current measles outbreak spreading across multiple states as evidence of what happens when vaccine confidence erodes.
Broader Implications for Public Health
Marks’ departure comes at a significant moment for public health in America. The United States is currently experiencing measles outbreaks that threaten its status of having eliminated domestic transmission of the disease. Marks claims that these outbreaks are direct results of what he believes is misinformation about vaccines.
The resignation also occurs amid reports that HHS under Kennedy’s leadership is planning significant workforce reductions, with up to 10,000 workers potentially being laid off and certain agencies facing closure. Kennedy has criticized the department as inefficient and blamed its workers for declining health metrics among Americans. These planned changes, coupled with Marks’ resignation, signal a potentially dramatic shift in how vaccine safety and public health policy will be managed.
Response from Health Community
The establishment health and scientific community has responded strongly to Marks’ departure. Dr. Paul Offit characterized the situation as Marks being “fired” for refusing to support Kennedy’s “misinformation campaign.” Former FDA Commissioner Dr. Robert Califf expressed hope that the development would strengthen communication between academia, industry, and government about the importance of evidence-based policies.
An unnamed HHS official defended the change in leadership, stating that Marks “has no place at FDA” if he was unwilling to support what they described as “restoring science to its golden standard and promoting radical transparency” under Kennedy’s direction. This suggests fundamentally different interpretations of scientific principles and transparency between the current HHS leadership and career officials like Marks.
Dr. Suzanne Humphries, former board-certified nephrologist and co-author of Dissolving Illusions: Disease, Vaccines, and the Forgotten History, just made a bombshell appearance on The Joe Rogan Experience—and what she shared will completely change how you think about vaccines.… pic.twitter.com/s3k50BXWnE
— The Vigilant Fox 🦊 (@VigilantFox) March 27, 2025